In January, a Panamanian court authorized house arrest for Noriega so he could undergo brain surgery to remove a benign brain tumor.
Noriega's tenure was marked by initial US support, accusations of widespread corruption and collaboration with the worldwide drug trade, and the U.S invasion of Panama.
In recent years, Noriega, who was known as "Pineapple Face" for his pockmarked complexion, had suffered various ailments, including high blood pressure and bronchitis.
It wasn't long before Noriega's benefactor, the USA, would turn on him, however.
Dubbed "mi gangster" by Torrijos, Noriega orchestrated the disappearance of scores of opponents, some of whose bodies later turned up in exhumations at the former Tocumen military base, bound and showing signs of torture.
A lawyer for the late Panamanian dictator Manuel Noriega says there is no official word on what caused his death.
His last years were spent in prison in Panama for murder, corruption an embezzlement. After the United States extradited him to France, a court there approved a request from Panama in December 2010 to send him back home, where he was convicted again. Tensions with the United States began mounting in 1985 when Noriega dismissed Nicolas Ardito Barletta, Panama's first democratically elected president in 16 years.
After Noriega became leader of the country, he was considered a valued Central Intelligence Agency asset and paid millions of dollars for assistance to the United States throughout Latin America.More news: Medical shops down shutters in Telangana
More news: More sponsors pull out of New York's Puerto Rican Day parade
More news: Gianforte wins Montana special election, apologizes to bodyslammed reporter
In June 1987, Noriega's former chief of Staff, Colonel Roberto Diaz Herrera, accuses him of electoral fraud, drug trafficking and the murder of Spadafora. In 2015, he asked the country for forgiveness for his notorious rule.
Noriega ruled Panama from 1983 to 1989.
-May 17, 1984: Electoral court declares Noriega-backed Nicholas Ardito Barletta as victor of presidential election as opposition alleges fraud.
The invasion ordered by President George HW Bush brought an end to his career of money-laundering and cocaine smuggling, in which he worked with traffickers like Colombian Pablo Escobar. On Dec. 20, citing Noriega's indictment on charges of racketeering, money laundering and drug-trafficking, the administration launched Operation Just Cause, an invasion force of more than 20,000 troops meant to oust him from power.
He is survived by his wife Felicidad and daughters Lorena, Thays and Sandra.
Noriega was later tried in France following his extradition from the United States in 2010 and was sentenced to seven years in prison. But they did concoct a plan to smoke out Noriega, who died Monday at the age of 83.
Noriega was trained at the School of the Americas, which provided military training to the governments of US-backed Latin American nations. As part of the operation, USA military invaded Panama and took control of Noriega. "Nobody else ever went to prison".